Salut Morphine18 , j ai tenté d espacer les prises , j ai tenté un cachet tout les deux jours et c est a ce moment que j ai eu les douleurs les plus vives.Je suis ensuite passé a 0,5 et j avais encore des douleurs,peut etre un peu moins prenantes,quoique...
Mais bon en meme temps maintenant que je me suis lancé dans la greffe je n ai plus trop le choix,je vais donc patienter un peu et voir ce que les choses donnent avec l arret du fina mais a moins d un miracle je pense que je serai obligé d en reprendre a un moment donné.
Je vais donc tout particulierement suivre ton cas morphine car si je reprends un traitement ca sera a 1/3 voir 1/4 de la dose habituelle.

Moi j ai pas de gosses,et ca me fait un peu flipper aussi cette histoire de sterilité,je pense que je passerai les axamens necessaires quand j aurais purgé tout le finasteride.Ca me foutrait bien les boules de perdre mes tifs,de racker pour une greffe pour au final se retrouver chauve avec les couilles atrophiées.
Bon,je dramatise pas non plus au niveau de mes burnes,les douleurs ca a tendence a s attenuer de + en +,c est relou j ai du envoyer chier une nana ce week end car j ai parfois encore mal et je suis pas super en confiance encore avec ca.
Mais je dois avouer que le shedding et l eventuel probleme de sterilité m enchantent vraiment pas quand j y pense.

Je retournerai voir l urologue qui m a examiné dans 1 mois et demi pour faire un premier bilan,je lui demanderai d etre un peu plus concret au sujet des tetards.Si quelqu un a des infos en attendant,il est vraiment le bienvenu.

Finastéride

Effets secondaires

Des effets secondaires d'ordre sexuel sont observés dans 1 à 2 % des cas : baisse de la libido, dysfonction érectile, anomalie de l'éjaculation. Ils sont réversibles en 15 jours à l'arrêt du traitement. Ils sont souvent transitoires malgré la poursuite du traitement [18].

D'autres effets secondaires ont été rarement rapportés : réactions d'hypersensibilité comprenant éruption cutanée, prurit, urticaire et gonflement des lèvres et du visage, sensibilité de la poitrine et gynécomastie [58], douleurs testiculaires.

Plouc,c est les chiffres officiels publiés par Merck,non ? Tu crois que l on peut se fier a ses chiffres ?

Moi perso j ai du mal a y croire a voir le nombre de gens qui se plaignent de ce medoc.

Je vais te balancer de l'étude qui ne vient pas de Merck alors :

A propos de l'infertilité :

"Finasteride is a specific inhibitor of the 5alpha reductase enzyme originally approved for the treatment of benign prostatic hypertrophy and also for the treatment of androgenetic alopecia (AGA) in men at a dose of 1 mg/day. We report on three cases of young men recruited at our Centre for Male Infertility who had used finasteride for five years. Semen quality was investigated by light microscopy to evaluate sperm concentration and motility. Sperm morphology was performed by transmission electron microscope (TEM) and the data were analyzed. The presence of Y microdeletions was investigated by PCR. Meiotic segregation was explored by fluorescence in situ hybridization (FISH). Patient 1 was azoospermic, patients 2 and 3 showed a normal sperm concentration and severely reduced progressive motility. TEM analysis revealed altered sperm morphology consistent with necrosis and FISH data revealed elevated diploidy and sex chromosome disomy frequencies. This examination was repeated 1 year after the men had suspended the use of finasteride, without receiving any other treatment. A recovery of spermatogenetic process was observed. Motility and morphology improved whereas the meiotic pattern did not change presenting elevated diploidy and sex chromosome disomy frequency."

Un autre:
"Finasteride is a potent and specific inhibitor of the 5alpha-reductase enzyme in men. Clinical studies have shown that finasteride 1mg/day is effective for promoting hair growth in men with male pattern hair loss. However, there is a concern about the use of finasteride, especially in young fertile patients, because of its action on testosterone _meta_bolism. This paper describes 3 cases of young patients who had very poor seminal quality during finasteride treatment (1 mg/day), and their seminal quality greatly improved after cessation of finasteride treatment. Two of them presented with a left varicocele and the other was obese. We hypothesize that finasteride may not dramatically change the spermatogenesis process in healthy men, but in patients with conditions related to infertility, an amplification of the negative influence of finasteride could occur. Future studies should be done to clarify the extent of the effect of finasteride in patients fertility problems."

Finasteride et dépression:

"BACKGROUND: Finasteride is a competitive inhibitor of 5 alpha-reductase enzyme, and is used for treatment of benign prostatic hyperplasia and androgenetic alopecia. Animal studies have shown that finasteride might induce behavioral changes. Additionally, some cases of finasteride-induced depression have been reported in humans. The purpose of this study was to examine whether depressive symptoms or anxiety might be induced by finasteride administration. METHODS: One hundred and twenty eight men with androgenetic alopecia, who were prescribed finasteride (1 mg/day) were enrolled in this study. Information on depressed mood and anxiety was obtained by Beck Depression Inventory (BDI), and Hospital Anxiety and Depression Scale (HADS). Participants completed BDI and HADS questionnaires before beginning the treatment and also two months after it. RESULTS: Mean age of the subjects was 25.8(+/- 4.4) years. At _base_line, mean BDI and HADS depression scores were 12.11(+/- 7.50) and 4.04(+/- 2.51), respectively. Finasteride treatment increased both BDI (p

Finasteride Vs Minoxidil 5% (pour autant que ce soit intéressant de les opposer):

"BACKGROUND AND AIM: Androgenetic alopecia (AGA) is undoubtedly the most common form of hair loss in males. It is a condition which may cause cosmetic and psychosocial problems in androgen-dependent cases. In this open, randomized and comparative study we evaluated the efficacy of oral finasteride and 5% topical minoxidil treatment for 12 months in 65 male patients with mild to severe AGA. METHODS: We randomly assigned 40 (61.53%) patients to receive 1 mg/day oral finasteride for 12 months, and 25 (38.47%) patients applied 5% topical minoxidil solution twice daily for 12 months. RESULTS: There were no significant differences between the 2 groups considering age, age of onset of hair loss, family history and type of hair loss (p > 0.05). In the clinical evaluation at the endpoint of treatment, the clinical cure rates (i.e. increased intensity of hair) were 80% (32/40) for the oral finasteride group and 52% (13/25) for the 5% topical minoxidil group. Encountered side effects were all mild, and there was no need to stop the treatment. In the group given oral finasteride, side effects were noted in 7 patients: 6 patients suffered from loss of libido, and 1 patient had an increase in other body hairs; irritation of the scalp was seen in 1 patient in the group administered 5% minoxidil. These adverse events disappeared as soon as the treatment was stopped. The laboratory data on both drug groups did not show any statistically or clinically significant intragroup changes from _base_line values to the endpoint (p > 0.05), except the level of serum total testosterone which was increased, and free testosterone and serum prostate-specific antigen in the finasteride group which were statistically decreased from _base_line values to the endpoint (p

Finastéride +/- minoxidil :

"Our understanding of the aetiology of androgenetic alopecia (AGA) has substantially increased in recent years. As a result, several treatment modalities have been tried with promising results especially in early stages of AGA. However, as far as has been ascertained, there is no comprehensive study comparing the efficacy of these agents alone and in combination with each other. One hundered male patients with AGA of Hamilton grades II to IV were enrolled in an open, randomized, parallel-group study, designed to evaluate and compare the efficacy of oral finasteride (1 mg per day), topical 2% minoxidil solution and topical 2% ketoconazole shampoo alone and in combination. They were randomized into four groups. Group I (30 patients) was administered oral finasteride, Group II (36 patients) was given a combination of finasteride and topical minoxidil, Group III (24 patients) applied minoxidil alone and Group IV (10 patients) was administered finasteride with topical ketoconazole. Treatment efficacy was assessed on the basis of patient and physician assessment scores and global photographic review during the study period of one year. At the end of one year, hair growth was observed in all the groups with best results recorded with a combination of finasteride and minoxidil (Group II) followed by groups IV, I and III. Subjects receiving finasteride alone or in combination with minoxidil or ketoconazole showed statistically significant improvement (p

Bonjour à tous !

un petit bilan au bout de 8 mois de dutas à raison de 1 cachet tous les 4 jours ; depuis 1 quinzaine de jours je peux noter un retour à la normale de la "qualité " du sperme qui dès le premier jour de traitement était devenu beaucoup plus fluide.

Et aussi une nette augmentation de la libido ! mais ça va ,ce n'est pas un effet secondaire trop gênant pour moi

Pour rappel j'ai 42 ans avec un norwood 2 qui s'est accru soudainement il y a un peu plus de 1 an et demi .


depuis une vingtaine d'années je regarde le nombre de cheveux au fond de la baignoire ;c'est la nette augmentation (une cinquantaine certains jours )qui m'a mis la puce à l'oreille et la remarque de ma femme qui s' est aperçu du recul soudain d'un golfe lors de ma coupe trimestrielle de cheveux qui m'a fait démarrer les médocs car autrement mes golfes se sont creusés que très très lentement .



Dès le deuxième mois sous dutas ,tout est rentré dans l'ordre au niveau du nombre de cheveux retrouvés et j'ai l'impression qu'en huit mois je n'ai pas eu de recul de mes golfes .

Bonjour à tous,

Petit update afin de savoir l'avancement de ton cas Boulichon ?

Qu'en est-il de l'atrophie constatée (et donc des douleurs) ?
La qualité de ton sperme est-elle rentrée dans les normes ?

Je vais poster l'historique du traitement d'un gars sous fina puis sous duta dans un autre topic...