Les Plantes intéréssantes.

[blmars french]

Je posterais ici toutes les infos intéréssantes que j'ai trouvé sur les plantes contre la perte des cheveux.
faites en de même avec des résultats clinique sérieux, merci.

Je commence avec la rose de chine (Hibiscus rosa-sinensis)
http://fr.wikipedia.org/wiki/Hibiscus_Rose_de_Chine

In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn
les cobayes sont des rats wistar albinos comme pour l'expe sur l'eclipta alba. Si on compare les resultats (ratio anagene/telogene) ils sont a peu près égaux.
(Par contre hibiscus était concentré à 1% et EA à 5%.)
Ratio anagene/telogene à 30j : 67/33 , placebo : 50/50


http://www.ncbi.nlm.nih.gov/pubmed/12963149

Abstract

Petroleum ether extract of leaves and flowers of Hibiscus rosa-sinensis was evaluated for its potential on hair growth by in vivo and in vitro methods. In vivo, 1% extract of leaves and flowers in liquid paraffin was applied topically over the shaved skin of albino rats and monitored and assessed for 30 days. The length of hair and the different cyclic phases of hair follicles, like anagen and telogen phases, were determined at different time periods. In vitro, the hair follicles from albino rat neonates were isolated and cultured in DMEM supplemented with 0.01 mg/ml petroleum ether extract of leaves and flowers. From the study it is concluded that the leaf extract, when compared to flower extract, exhibits more potency on hair growth.

[blmars french]

procyanidines de pomme :
la procyanidin B-3 inhibe l'action du TGF-beta1

en gros, la procyanidin B2 et C1 permettrait la promotion de la pousse des cheveux. cette molecule etant contenue dans la pomme, appliquée en topique, et l'action serait une stimulation de 300% combinée au minoxidil.

[blmars french]

Ginseng :
efficacité>>minox5% sur souris. Augmente Bcl-2 et diminue Bax.


PANAX GINSENG, ITS EFFECTS ON DEVELOPMENT
OF HAIR FOLLICLES – AN EXPERIMENTAL STUDY (2012)

Introduction: The use of Herbal medicines in developed and developing countries is rapidly increasing
on the presumption that they are better and safer than conventional medicines. It is now
being reported that herbal preparations have far reaching effects on body systems especially in the
developmental processes. The current study was conducted to evaluate the effect of Panax ginseng
on developing hair follicle of albino mice.
Materials and Methods: Thirty mice, 6 – 8 weeks old weighing 30 – 35 gm were housed together
for mating and pregnancy was confirmed by vaginal plug. The fetuses were delivered and dissected
on the 19th day and the fetuses were delivered, microscopic slides of the hair follicles small pieces
of skin were removed and processed for to be examined under light microscope.
Results and Conclusion: The pregnant dams were treated with Panax Ginseng and the litter obtained
showed an increase in the number of hair follicles. Histological sections showed signs of haemorrhages
and tissue degeneration. Although, embryo – toxicity in experimental model of animals
may not reflect the situations in humans, further investigation and monitoring of the adverse effects
of the Panax ginseng during pregnancy is warranted in humans.

http://www.thebiomedicapk.com/​articles/282.pdf

Effects of ginseng rhizome and ginsenoside Ro on testosterone 5α-reductase and hair re-growth in testosterone-treated mice (2012)

This research program on the novel functions of Panax ginseng C. A. Meyer focused on the effects of ginseng rhizome on hair re-growth in androgenetic alopecia. Extracts of red ginseng rhizome showed greater dose-dependent inhibitory effects against testosterone 5α-reductase (5αR) when compared with extracts of the main root. Ginsenoside Ro, the predominant ginsenoside in the rhizome, and ginsenoside Rg(3), a unique ginsenoside in red ginseng, showed inhibitory activity against 5αR with IC(50) values of 259.4 and 86.1 µm, respectively. The rhizome of P. japonicus, which contains larger amounts of ginsenoside Ro, also inhibited 5αR. Topical administration of extracts of red ginseng rhizomes (2 mg/mouse) and ginsenoside Ro (0.2 mg/mouse) to shaved skin inhibited hair re-growth suppression after shaving in the testosterone-treated C57BL/6 mice. These results suggest that red ginseng rhizomes containing both oleanane- and dammarane-type ginsenosides are a promising raw material for cosmetic use. This is the first report that ginsenoside Ro enhances in vivo hair re-growth based on their inhibitory activity against 5αR in the androgenetic alopecia model.

http://onlinelibrary.wiley.com​ [...] .3511/full

Fructus panax ginseng extract promotes hair regeneration in C57BL/6 mice (2011)

ETHNOPHARMACOLOGICAL RELEVANCE:
Radix panax ginseng (Panax ginseng C.A. Meyer, Araliaceae, RPG) has been documented to possess hair growth activity and widely used to treat alopecia, while no report has been issued to date on the effect of Fructus panax ginseng (FPG) on hair regeneration.
MATERIALS AND METHODS:
To investigate the effects of FPG extract on the proliferation of human hair dermal papilla cells (DPCs) and on the promotion of hair regeneration in C57BL6 mice, cell proliferation was evaluated in cultured DPC by 3-(4,5-dimethylthiazol-2-yl)-2​,5-diphenyl tetrazolium bromide (MTT) and measured the expressions of Bcl-2 and Bax by immunoblot assay. We also compared the effects of topical FPG extract (1 and 10 mg/ml, 100 μl/d) with the effects of minoxidil as a positive control (5%, 100 μl/d) or vehicle control (30% ethanol) on the depilation-induced hair cycling in 7 week-old-C57BL/6 mice.
RESULTS:
FPG extract significantly increased the proliferation of DPCs in dose and time dependent manners (P<0.05, P<0.01 and P<0.001). FPG extract also enhanced Bcl-2 expression and decreased Bax expression compared with control (P<0.01). Moreover, significant elongations of anagen phase during hair cycle after application of FPG were evaluated by photographical and histological observations.
CONCLUSIONS:
FPG extract improves the cell proliferation of human DPCs through anti apoptotic activation. Topical administration of FPG extract might have hair regeneration activity for the treatment of hair loss.

http://www.folikul.com/ginseng​2.pdf

Effect of Ginseng Extract on the Follicular Growth of C_(57)BL/6J Vibrissa (2005)

Aim To culture the follicle of C_ 57BL/6J vibrissa and to investigate the best concentration of ginseng extract for promoting the growth of mouse hair follicle.Methods The whole hair follicles of C_ 57BL/6J mice in anagen were picked up under the anatomic microscope,put in Willimas E culture medium containing different concentrations of ginseng extract and incubated in a box at 37℃and 5% CO_2.The length of hair shaft was measured once every 24 hours.After a culture of 24 hours,3H-TdR 50μl(0.5μC_i) was added to every aperture.The follicles were fixed with 10% trichloroacetic acid under ice bath.They were digested to lysis completely with 0.3mol·L -1 NaOH in water bath with 37℃.The cells were collected to 999 type fibrous membrane and were dried.The flicker liquid was added and measured with LS-6500 counting equipment.Results Ginseng extracts can hair growth when their concentratins are between 0.005mg·ml -1 to 0.1mg·ml -1.Extract of ginseng produces the best effect at concentration of 0.1mg·ml -1.Conclusion Ginseng extract can promote hair growth.

http://en.cnki.com.cn/Article_​ [...] 506005.htm (abstract)

Promotion of hair growth by ginseng radix on cultured mouse vibrissal hair follicles (2003)

A 70% methanol extract from red ginseng (steamed and dried roots of Panax ginseng C. A. Meyer, a kind of Ginseng Radix) had superior activity to that of white ginseng (peeled and dried root of P. ginseng, another kind of Ginseng Radix) in a hair growth promoting assay using mouse vibrissal follicles in organ culture. Of the major constituents of P. ginseng, ginsenoside-Rb(1) (G-Rb(1)) exhibited activity, but ginsenoside-Rg(1) (G-Rg(1)) and -Ro (G-Ro) were ineffective. Additionally, 20(S)-ginsenoside-Rg(3) (20(S)-G-Rg(3)) formed by the processing of red ginseng from the crude root of P.ginseng also showed hair growth promoting activity. These results indicate that Ginseng Radix possesses hair growth promoting activity, and its bioactive components are partially attributable to the ginseng saponin components mentioned above.

http://www.boonmeeherb.com/ima​ [...] motion.pdf

Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice (1998)

We studied the effect of the water fraction of Panax ginseng, one of traditional oriental medicine herbs on apoptosis and the formation of medullary cell in the hair follicles of irradiated mice. The hair follicle or its differentiated product, the hair, which represents a linear historical record of follicular proliferative activity, could provide a biological indicator of the effect of radioprotective drugs. Adult N:GP(s) mice with hair follicles synchronously in the middle of the hair growth cycle received whole-body doses of gamma-radiation. The hair follicles were analysed either 12 hours after irradiation with 2 Gy in the experiment on the apoptosis, or 3 days after irradiation with 3 Gy in the experiment on the forming medulla. The number of medullary cells per unit length (100 microns) were measured by H and E staining. Apoptosis was detected by a nonisotopic in situ DNA end-labeling (ISEL) technique and H and E stain applied to the serial histologic sections. Ginseng administration before irradiation resulted in a suppression of apoptosis, as shown by a reduced number of cells stained with ISEL for fragmented DNA, both i.p. (0.3 mg/head, p < 0.05) and p.o. (2 mg/ml of drinking water, p < 0.05) treatment. In addition, ginseng treatment was associated with an increase in the number of medullary cell per unit length as compared with the vehicle treated mice (p < 0.001, i.p.; p < 0.05, p.o.). These results indicate that the water fraction of ginseng can exert a potent effect on the recovery of the hair follicles by its combined effects on proliferation and apoptosis of the cells in the hair follicle.

http://www.ncbi.nlm.nih.gov/pu​bmed/9627805 (abstract)

voir photos où on voit une nette supériorité sur le minoxidil 5%
Fructus panax ginseng extract promotes hair regeneration in C57BL/6 mice


http://ars.els-cdn.com/content [...] 61-gr3.jpg

http://ars.els-cdn.com/content [...] 61-gr4.jpg

http://ars.els-cdn.com/content [...] 61-fx1.jpg


(je le prend depuis quelques semaines je remarque des érections de très très bonne qualité (j'ai pas de souci a la base) mais la c'est vraiment ++)

J'ai fait quelques petites recherche pour comprendre s'il y avait pas un lien entre l’extraie de ginseng et le récepteur de la vitamine D.
Résultat une étude très intéressant sur la synergie du ginseng avec la vitamine D3, sur la différenciation des cellules leucémique. On pourrai extrapoler cela aux cellules du follicule pileux.
Le ginseng pourrai agir sur des voix de signalisation similaire a celle de la vitamine D3.
https://www.jstage.jst.go.jp/a​ [...] 80823/_pdf

La différenciation et inférieur a 5% avec l'extraie de ginseng. Elle est a 18 % avec la vitamine D3 et si on met vitamine D3 +ginseng la on a 70 % de différenciation ça c'est très intéressante.
Il pourrait donc être très intéressante de prendre une supplémentation en GINSENG ROUGE accompagné de la VIT D3.

[blmars french]

La Framboise

Ils ont testé sur des gens et en à peine 5 mois ils ont constaté des résultats positifs sur la calvitie. Ils ont également constaté des effets positifs sur l'élasticité de la peau en 2semaines seulement.

Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans

Sensory neurons release calcitonin gene-related peptide (CGRP) on activation. We recently reported that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal insulin-like growth factor-I (IGF-I) production through activation of sensory neurons in mice and humans. Raspberry ketone (RK), a major aromatic compound contained in red raspberries (Rubus idaeus), has a structure similar to that of capsaicin. Thus, it is possible that RK activates sensory neurons, thereby increasing skin elasticity and promoting hair growth by increasing dermal IGF-I production. In the present study, we examined this possibility in mice and humans. RK, at concentrations higher than 1 microM, significantly increased CGRP release from dorsal root ganglion neurons (DRG) isolated from wild-type (WT) mice and this increase was completely reversed by capsazepine, an inhibitor of vanilloid receptor-1 activation. Topical application of 0.01% RK increased dermal IGF-I levels at 30 min after application in WT mice, but not in CGRP-knockout mice. Topical application of 0.01% RK increased immunohistochemical expression of IGF-I at dermal papillae in hair follicles and promoted hair re-growth in WT mice at 4 weeks after the application. When applied topically to the scalp and facial skin, 0.01% RK promoted hair growth in 50.0% of humans with alopecia (n=10) at 5 months after application and increased cheek skin elasticity at 2 weeks after application in 5 females (p<0.04). These observations strongly suggest that RK might increase dermal IGF-I production through sensory neuron activation, thereby promoting hair growth and increasing skin elasticity.




Sponsored Ad
Baldness will soon lose its label as a "non-curable" health condition. Several innovations are leading to the discovery of effective cure for baldness. Most recently scientists found that raspberry ketone can be an effective treatment for baldness.

Raspberry ketone is already known for its several health benefits. It is a well-known belly fat busting supplement. Raspberry ketones resemble capsaicin in chili pepper plants. Capsaicin is believed to have fat burning properties. Studies are in progress to further evaluate the efficacy of raspberry ketones as a supplement for weight loss.

The recent discovery which says raspberry ketones are effective in treating baldness is good news. The study by a Japanese research group finds that raspberry ketones induce hair growth in people with alopecia. In this study as well, the similarity between raspberry ketones and capsaicins is taken into consideration. Previous research has shown that capsaicins increase the expression of a dermal (skin) insulin-like growth factor that increases skin elasticity and promotes hair growth.

To substantiate this finding, researchers conducted clinical study on randomly selected test subjects. The researchers applied a topical cream containing a raspberry ketone extract as the active ingredient on the skin of mice and on the facial skin and scalp of humans with alopecia.

The researched proved that in mice the raspberry ketone cream increased the expression of an insulin growth factor called "IGF-1" in the hair follicles and promoted hair re-growth in mice 4 weeks after application. In the human test subjects, the ketone extract resulted in hair growth in 50 percent of the test subjects with alopecia after 5 months; and, it also increased their cheek skin elasticity.

Following these findings, the researchers concluded that raspberry ketone might be exerting its observed effect on hair and skin by increasing insulin growth factor-1 production via sensory nerve action. It contains more medicinal value than just a belly fat busting supplement and has the potential for use in treating aging skin and in preventing or curing baldness in some people.

Meanwhile another study that could pave way to baldness cure hit headlines recently. Scientists have identified a protein which probably is the root cause for baldness in men. This discovery could lead to the development of a drug that may offer an effective remedy for hair loss in men.

Researchers at Science Translational Medicine have identified an abnormal level of a protein called prostaglandin D2 (PGD2) on the bald spots of men. The study looked at the genes in scalp samples from five men and compared them to the haired parts from same individuals. It revealed higher expressions of the gene that produces PGD2 in the bald samples, compared to the spots with hair. The research led to the conclusion that PGD2 was three times higher in the bald spots than where hair was growing. The scientists then validated the results through tests on mice and concluded that excessive PGD2 decreased follicle density.

[blmars french]

Le Mahakanni/ Eclipta alba

http://fr.wikipedia.org/wiki/Mahakanni
Augmente le IGF-1, structure similaire à capsaicine

Hair growth promoting activity of Eclipta alba in male albino rats
Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. Eclipta alba Hassk. is a well-known Ayurvedic herb with purported claims of hair growth promotion. In the reported work attempts were undertaken to evaluate petroleum ether and ethanol extract of E. alba Hassk. for their effect on promoting hair growth in albino rats. The extracts were incorporated into oleaginous cream (water in oil cream base) and applied topically on shaved denuded skin of albino rats. The time (in days) required for hair growth initiation as well as completion of hair growth cycle was recorded. Minoxidil 2% solution was applied topically and served as positive control for comparison. Hair growth initiation time was significantly reduced to half on treatment with the extracts, as compared to control animals. The time required for complete hair growth was also significantly reduced. Quantitative analysis of hair growth after treatment with petroleum ether extract (5%) exhibited greater number of hair follicles in anagenic phase (69 ± 4) which were higher as compared to control (47 ± 13). The result of treatment with 2 and 5% petroleum ether extracts were better than the positive control minoxidil 2% treatment.

[blmars french]

La baicaline (Scutellaria baicalensis) réactive des follicules pileux rendus inactifs par l’action négative que les androgènes exercent sur eux. Plante médicinale, utilisée de longue date en Orient, pour ses vertus anti-âge et anti-oxydantes, la baicaline contient une protéine, la TERC, présente naturellement dans le corps humain. Appliquée localement sur les cuirs chevelus prédisposés aux pertes de cheveux androgénétiques, la protéine TERC a un impact direct sur le processus de fabrication des cheveux et s’avère être un anti chute très actif.

Il y a très peu d'info sur cette plante Scutellaria baicalensis sur les cheveux mais elle est interessant pour pleins d'autres fonctions.
Ici une étude sur sont effet sur le VEGF indispensable a la bonne vascularisation du cheveux.( Apparament elle aurait un effet similaire au latanoprost (le produit XALATAN)).

http://www.pifukezazhi.com/EN/abstract/ ... 1808.shtml

http://fr.wikipedia.org/wiki/Baicaline

[blmars french]

Anis étoilée (acide shikimique) :

http://fr.wikipedia.org/wiki/Badiane_chinoise

Exp Dermatol. 2004 Aug;13(8):499-504. Related Articles, Links

The water-soluble extract of Illicium anisatum stimulates mouse
vibrissae follicles in organ culture.

Sakaguchi I, Ishimoto H, Matsuo M, Ikeda N, Minamino M, Kato Y.

Research & Development Division, Club Cosmetics Co., Ltd, Ikoma-shi,
Nara 630-0222, Japan.

Sakaguchi I, Ishimoto H, Matsuo M, Ikeda N, Minamino M, Kato Y. The
water-soluble extract of Illicium anisatum stimulates mouse vibrissae
follicles in organ culture.Abstract: It is well known that reduced blood
flow in the scalp is a cause of alopecia. We have shown previously that
the extract of Illicium anisatum increases subcutaneous blood flow in
mice. In the present study, we used an organ culture system to examine
whether this extract promoted hair follicle elongation. B6C3HF1 mouse
vibrissae follicles were cultured in serum-free medium for 7 days at 31
degrees C. Follicles treated with water-soluble (WS) extracts of the
leaves, fruits and roots of Illicium anisatum or shikimic acid grew
significantly longer than controls. In contrast, ethyl acetate-soluble
(AS) extracts and n-hexane-soluble (HS) extracts of the leaves, fruits
and roots of the plant inhibited hair follicles and shaft growth.
Fractionation of the WS fruit extract showed that the number 1 and
number 2 fractions possessed hair follicle elongation activity. GC/MS
analysis revealed that the number 1 fraction contained shikimic acid,
and that the number 2 fraction was a mixture of many components
including glycosides and polysaccharides. Reverse
transcription-polymerase chain reaction analysis demonstrated that
shikimic acid also induced mRNA expression of insulin-like growth
factor-1, keratinocyte growth factor, and vascular endothelial growth
factor in the hair follicles. These results suggest that the WS extract
of Illicium anisatum promotes hair growth and may be a useful additive
in hair growth products.

PMID: 15265014 [PubMed - in process]




An Esp Pediatr. 2002 Oct;57(4):290-4. Related Articles, Links
Click here to read
[Cases of neurological symptoms associated with star anise
consumption used as a carminative]

[Article in Spanish]

Garzo Fernandez C, Gomez Pintado P, Barrasa Blanco A, Martinez
Arrieta R, Ramirez Fernandez R, Ramon Rosa F; Grupo de Trabajo del Anis
Estrellado.

Hospital General Universitario Gregorio Maranon, Madrid, Spain.

BACKGROUND: Since March 2000, a series of infants with serious
gastrointestinal and neurological symptoms have been observed in Spain.
These symptoms were suspected to be associated with the use of star
anise infusion. We performed an epidemiological study to determine the
characteristics of these patients and to evaluate the association
between the symptoms and anise consumption. METHOD: From February to
September 2001, a matched case-control study (1:2) was performed among
infants aged less than 3 months admitted to the pediatric emergency
departments of two hospitals in Madrid. Mantel-Haenszel and conditional
logistic regression odds ratios (OR) were calculated to quantify the
association and the dose-response relationship. Laboratory analyses of
the implicated substances were performed. RESULTS: Twenty-three cases
were studied. The mean age was 29.2 days (SD: 25.5). The symptoms
observed were irritability, abnormal movements, vomiting and nystagmus.
Eighteen cases and 36 controls were included in the case-control study.
Nine controls (25 %) consumed anis infusion (consumption was high in
five and low in four). The Mantel-Haenszel OR was 18.0 (2.03-631) and
the OR for the dose-response relationship was 11.7 (95 % CI: 1.3-188.5)
for low levels of consumption and 18.2 (95 % CI: 1.8-183.5) for high
levels. Laboratory analyses revealed contamination of Illicium verum by
Illicium anisatum. CONCLUSIONS: This study confirms the association
between the symptoms described and the use of anise infusion. The dose
response analyses provide further evidence for the association.
Cross-contamination was found between the product and other anise
species. We recommend destruction of the contaminated products,
avoidance of anise infusions among infants, and dissemination of the
results among pediatricians.

PMID: 12392661 [PubMed - indexed for MEDLINE]


14: Ned Tijdschr Geneeskd. 2002 Apr 27;146(17):813-6. Related Articles,
Links

Comment in:

* Ned Tijdschr Geneeskd. 2002 Apr 27;146(17):808-11.


[An epidemic of epileptic seizures after consumption of herbal tea]

[Article in Dutch]

Johanns ES, van der Kolk LE, van Gemert HM, Sijben AE, Peters PW, de
Vries I.

Nationaal Vergiftigingen Informatie Centrum van het Rijksinstituut
voor Volksgezondheid en Milieu en het Universitair Medisch Centrum te
Utrecht

At the end of September 2001 the Inspectorate for Health Protection
and Veterinary Public Health and the National Poisons Control Centre
(NPCC) were informed about adverse health effects after consumption of a
herbal tea. During consultations it was suggested that Japanese star
anise (Illicium anisatum L.), which is known to contain a neurotoxin,
may have been inadvertently mixed into the herbal tea. In view of the
severity of the adverse health effects and the clear association with
consumption of a specific herbal tea, the supplier was urgently advised
to withdraw the suspected herbal tea from the market. A total of 63
persons reported symptoms of general malaise, nausea and vomiting 2-4
hours following consumption of the herbal tea. Twenty-two persons
required hospitalisation, of whom 16 due to generalised tonic-clonic
seizures. Medical investigations revealed no underlying pathology and
after supportive treatment, the patients were discharged in good health.
Morphologic and organoleptic investigations of the suspected herbal tea
indicated that this possibly contained Japanese star anise. NMR analysis
of the herbal tea confirmed the presence of the neurotoxin anisatin, a
non-competitive GABA-antagonist which can cause hyperactivity of the
central nervous system and tonic-clonic seizures. CONCLUSION: Ingestion
of a herbal tea containing anisatin caused the reported serious adverse
health effects. Close cooperation between clinicians, the Inspectorate
for Health Protection and Veterinary Public Health and the NPCC played a
vital role in preventing further harm to public health.

Publication Types:

* Case Reports


PMID: 12014242 [PubMed - indexed for MEDLINE]

Phytother Res. 2002 Feb;16(1):94-5. Related Articles, Links
Click here to read
Antimicrobial properties of star anise (Illicium verum Hook f).

De M, De AK, Sen P, Banerjee AB.

Department of Biochemistry, University College of Science, 35
Ballygunge Circular Road, Calcutta 700 019, India.

Star anise (Illicium verum Hook f) has been shown to possess potent
antimicrobial properties. Chemical studies indicate that a major portion
of this antimicrobial property is due to anethole present in the dried
fruit. Studies with isolated anethole (compared with standard anethole)
indicated that it is effective against bacteria, yeast and fungal
strains. Copyright 2002 John Wiley & Sons, Ltd.

PMID: 11807977 [PubMed - indexed for MEDLINE]

[blmars french]

L'huile de jujube

http://kcms.daegu.ac.kr/user/sck1111/ne ... 5_2010.pdf

[blmars french]

racine d'Asaret
http://fr.wikipedia.org/wiki/Asaret_d%27Europe

augmente le VEGF (mais pas IGF-1, KGF, HGF) n'inhibe pas la 5ar

The hair growth promoting effect of Asiasari radix extract and its molecular regulation.
Abstract
BACKGROUND:

Hair loss is a distressing condition for an increasing number of men and women. It is of great importance; therefore, to develop new therapies for the treatment of hair loss.
OBJECTIVE:

We examined the effects of 45 plant extracts that have been traditionally used for treating hair loss in oriental medicine in order to identify potential stimulants of hair growth.
METHODS:

Six-week-old female C57BL/6 and C3H mice were used for evaluating the hair growth-promoting effects of the plant extracts. Topical application onto the backs of the C57BL/6 and C3H mice was performed daily for 30 days and 45 days, respectively. Protein synthesis was measured by the cysteine uptake assay, using cultured murine vibrissae follicles. Proliferation of the immortalized human keratinocyte cell line (HaCaT) and human dermal papilla (DP) cells was evaluated by the MTT and thymidine incorporation assays. The mRNA levels of several growth factors that have been implicated in hair growth control were measured by reverse transcription-polymerase chain reaction (RT-PCR).
RESULTS:

Among the tested plant extracts, the extract of Asiasari radix showed the most potent hair growth stimulation in C57BL/6 and C3H mice experiments. In addition, this extract markedly increased the protein synthesis in vibrissae follicle cultures and the proliferation of both HaCaT and human DP cells in vitro. Moreover, the A. radix extract induced the expression of VEGF in human DP cells that were cultured in vitro.
CONCLUSION:

These results suggest that the A. radix extract has hair growth-promoting potential, and that this effect may be due to its regulatory effects on both cell growth and growth factor gene expression.

[blmars french]

Bruyère à nombreuses fleurs

http://fr.wikipedia.org/wiki/Bruy%C3%A8 ... ses_fleurs


Since it's been a while since I've written about exotic substances and hair growth, it's once again time to baldly go where no man has gone before and post some more news from the hair loss front.

Kawano et al. recently published a study suggesting that a plant called Erica multiflora increases hair growth in vitro and in vivo in mice. The abstract has already made its way into several discussion forums, but what does the full paper say?

Like true pioneers of scalp health, the authors collected several different plants from Tunisia and tested their effect on hair growth. Among the plants was Erica multiflora, an aromatic plant used in North Africa to treat inflammation and hypertension, which has also been shown to reduce cholesterol and triglyceride levels. It was extracted by immersing 10 grams of dried plant in 100 ml of 70% ethanol for two weeks and then filtered to remove plant parts and sterilize the extract.

In vitro hair growth effects of Erica multiflora

For the in vitro experiment, human follicular dermal papilla cells were treated with the extract. Out of the six plant extracts tested, only Erica multiflora significantly increased the growth of human follicular dermal papilla cells. Some of the plants actually tended to decrease hair growth.

The growth promotion activity of Erica multiflora was clear only when a high concentration extract was used. 500 mcg of extract per ml increased hair growth by 9%, while a concentration of 5,000 mcg per ml increased it by 44%.

Treating the cells with the extract for 12 hours stimulated the cells, while longer treatments did not have a similar effect. According to the authors, Erica multiflora had the ability to stimulate dermal papilla cell mitosis but not to promote DNA synthesis.

In vivo hair growth effects of Erica multiflora

For the in vivo experiment, the extract was applied on the backs of shaved mice. Since the mice were of the same age, they were known to be in the telogen (resting) phase of hair growth. The mice were then injected with the 500 mcg/ml extract or phosphate-buffered saline.

Hair growth was seen after 3 weeks of injection of Erica multiflora. The authors note that the extract stimulated the normal hair cycle, inducing hair follicles at the next anagen and telogen stages. Vasodilation also occurred near the anagen-stimulated area. They conclude that since there was a delay between the injection and increased hair growth, the extract stimulated the shift from telogen to anagen phase indirectly.

Conclusion

The extract of Erica multiflora stimulated human follicular dermal papilla cell growth by up to 44%. When injected onto the backs of shaved mice, the extract increased vasodilation and stimulated the change from the resting phase to the growth phase of hair.

[blmars french]

Sophora flavescens

http://en.wikipedia.org/wiki/Sophora_flavescens

Sophora flavescens is a species of plant in the genus Sophora a genus of the Fabaceae family, that contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands.About fifteen species in this genus have a long history of use in traditional Chinese medicines.[1] Ku shen (the root)[2] or kushenin (a pterocarpan, an isoflavonoid compound) is a typical traditional Chinese medicine[3] that is found in this plant. It is commonly used for the treatment of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage[4][non-primary source needed] and skin diseases (such as colpitis, psoriasis and eczema). Its roots contain quinolizidine alkaloids, includying matrine and its oxide, matrine oxide[5] that interfere TNF-alpha and IL-6, suggesting that oxymatrine may inhibit the expression of the above pro-inflammatory cytokines.[6] Matrine also inhibited expression of Substance P and NK-1R in a human model of skin inflammation,[7] as well as acting as an agonist at mu and kappa opioid receptors.


The hair growth promoting effect of Sophora flavescens extract and its molecular regulation.
Abstract

In search of natural extracts for hair growth, we found that the extract of dried root of Sophora flavescens has outstanding hair growth promoting effect. After topical application of Sophora flavescens extract onto the back of C57BL/6 mice, the earlier conversion of telogen-to-anagen was induced. The growth of dermal papilla cells cultured in vitro, however, was not affected by Sophora flavescens extract treatment. RT-PCR analysis showed that Sophora flavescens extract induced mRNA levels of growth factors such as IGF-1 and KGF in dermal papilla cells, suggesting that the effects of Sophora flavescens extract on hair growth may be mediated through the regulation of growth factors in dermal papilla cells. In addition, the Sophora flavescens extract revealed to possess potent inhibitory effect on the type II 5alpha-reductase activity. Taken together, these results suggest that Sophora flavescens extract has hair growth promoting potential and can be used for hair growing products.

[blmars french]

Schisandra nigra

Promotion effect of Schisandra nigra on the growth of hair.
Abstract

This study was conducted to evaluate the effect of Schisandra nigra, a plant native to Jeju Island, South Korea, on the promotion of hair growth. When rat vibrissa follicles were treated with 85% ethanol (EtOH) extract of S. nigra, the hair-fiber lengths of the vibrissa follicles increased significantly. In addition, after topical application of the EtOH extract of S. nigra onto the back of C57BL/6 mice every other day, anagen progression of the hair shaft was induced. Moreover, the extract increased both the expression of proliferating cell nuclear antigen (PCNA) in the bulb matrix region and the proliferation of immortalized vibrissa dermal papilla cells. In order to determine the mechanism by which S. nigra promotes hair growth, we examined its relationship with the transforming growth factor-beta2 (TGF-beta2) signal pathway, which is known to be a regulator of catagen induction. When the vibrissa follicles in the anagen phase were treated with S. nigra extract for 7 days, the expression of TGF-beta2 in the bulb matrix region was found to be lower than that of the control follicles that were expected to be in the anagen-catagen transition phase. These results suggest that S. nigra extract has the potential to promote hair growth via down regulation of TGF-beta2 and the proliferation of dermal papilla.

[blmars french]

Cryptomeria japonica

http://fr.wikipedia.org/wiki/Cryptomeria_japonica

The essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene.

Abstract

Chamaecyparis obtusa (C. obtusa) is a conifer in the cypress family Cupressaceae, native to northeast Asia. The essential oils of C. obtusa have antibacterial and antifungal effects and several products such as hygienic bands, aromatics, and shampoos contain these oils as a natural source of antimicrobial/antifungal agents. Interestingly, some consumers suffering from baldness and/or other forms of hair loss have reported a hair growth promoting effect of shampoos containing these oils. In the present study, the hair growth promoting effect of C. obtusa oils was elucidated in an animal model. C. obtusa oils promoted the early phase of hair growth in shaved mice. In addition, we examined the molecular effect of C. obtusa oils on the regulation of hair morphogenesis and hair growth using the human keratinocyte cell line HaCaT. In the current study of hair growth regulating genes, the expressions of vascular endothelial growth factor (VEGF), transforming growth factor (TGF beta 1), and keratinocyte growth factor(KGF) have been analyzed by real-time PCR in HaCaT cells. The essential oils of C. obtusa were divided into seven fractions for treatment of HaCaT cells. VEGF transcripts were induced by fractions 6 and 7; however, TGF beta 1 and KGF mRNA levels were unchanged by C. obtusa oils or fractions. Fraction 7 was separated into seven sub-fractions and studied further. Sub-fractions E and D significantly increased VEGF and KGF gene expression without up-regulating the hair growth inhibition factor, TGF beta 1. The components of the two sub-fractions were further analyzed by gas chromatography and mass spectrometry. Cuminol, eucarvone, and calamenene were common to these two sub-fractions, although the effects of these individual components were not determined. Taken together, these results suggest that C. obtusa oils promote hair growth in an animal model and a positive regulator of hair growth, VEGF, was induced by particular components of these oils.

[blmars french]

Crinum asiaticum (norgalanthamine)

http://fr.wikipedia.org/wiki/Crinum_asiaticum
Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth.

Abstract

This study was conducted to evaluate the effect of Crinum asiaticum, a plant native to Jeju Island, Korea, on the promotion of hair growth. When rat vibrissa follicles were treated with a 95% ethanol (EtOH) extract of C. asiaticum, the hair-fiber lengths of the vibrissa follicles increased significantly. In addition, after daily topical application of the EtOH extract of C. asiaticum onto the back of C57BL/6 mice, anagen progression of the hair shaft was induced. Moreover, the extract increased the proliferation of immortalized vibrissa dermal papilla cells. When the vibrissa follicles in the anagen phase were treated with the extract, immunohistochemical analysis revealed that the extract was found to increase the expression of proliferating cell nuclear antigen (PCNA) in the bulb region of the 7-day cultured follicles. In particular, norgalanthamine, a principal of the extract, showed activity that increased the hair-fiber lengths of vibrissa follicles and the proliferation of dermal papilla cells. These results suggest that norgalanthamine, a principal of C. asiaticum, has the potential to promote hair growth via the proliferation of dermal papilla

[blmars french]

Citrullus coclocynthis
http://fr.wikipedia.org/wiki/Coloquinte

http://omicsonline.org/2155-9554/2155-9554-3-148.php